2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

Base Information

Chemical Name:2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile
CAS No.:941693-40-9
Molecular Formula:C₂₀H₁₇N₃O₂
Molecular Weight:331.374
Hs Code.:

Synonyms:2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

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Chemical Property of 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

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Technology Process of 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

There total 10 articles about 2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 941693-37-4
2-bromo-4,6-dimethyl-3,5-dicarbonitrile

: 4039-83-2
3-(4-methoxybenzyloxy)propyne

: 941693-40-9
2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

Guidance literature:: 2-bromo-4,6-dimethyl-3,5-dicarbonitrile; With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; for 0.166667h;

3-(4-methoxybenzyloxy)propyne; In diethyl ether; at 20 ℃; Further stages.;
DOI:10.1021/ol070748n

Reference yield:

: 109703-07-3
C₉H₇N₃O

: 941693-40-9
2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / tetrabutylammonium bromide; P₂O₅ / toluene / 1 h / 100 °C

2.1: triethylamine; CuI / PdCl₂(PPh₃)2 / diethyl ether / 0.17 h

2.2: 84 percent / diethyl ether / 20 °C

With copper(l) iodide; tetrabutylammomium bromide; phosphorus pentoxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; toluene;
DOI:10.1021/ol070748n

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 941693-40-9
2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / NBS; trifluoroacetic acid; H₂SO₄ / 1.5 h

2.1: 65 percent / dimethylformamide / 48 h / Heating

3.1: 68 percent / tetrabutylammonium bromide; P₂O₅ / toluene / 1 h / 100 °C

4.1: triethylamine; CuI / PdCl₂(PPh₃)2 / diethyl ether / 0.17 h

4.2: 84 percent / diethyl ether / 20 °C

With N-Bromosuccinimide; copper(l) iodide; sulfuric acid; tetrabutylammomium bromide; phosphorus pentoxide; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol070748n