2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile
• CAS No.: 941693-43-2
• Molecular Formula: C₂₀H₂₁N₃O₂
• Molecular Weight: 335.406
• Mol file: 941693-43-2.mol

Synonyms:2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

Chemical Property of 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

There total 12 articles about 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile (941693-40-9) → 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile (941693-43-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 7h; under 2947.82 Torr;

DOI:10.1021/ol070748n

Reference yield:

2-bromo-4,6-dimethyl-3,5-dicarbonitrile (941693-37-4) → 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile (941693-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; CuI / PdCl₂(PPh₃)2 / diethyl ether / 0.17 h

1.2: 84 percent / diethyl ether / 20 °C

2.1: hydrogen / Pd/C / methanol / 7 h / 2947.82 Torr

With copper(l) iodide; hydrogen; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; diethyl ether;

DOI:10.1021/ol070748n

Reference yield:

3-(4-methoxybenzyloxy)propyne (4039-83-2) → 2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbonitrile (941693-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; CuI / PdCl₂(PPh₃)2 / diethyl ether / 0.17 h

1.2: 84 percent / diethyl ether / 20 °C

2.1: hydrogen / Pd/C / methanol / 7 h / 2947.82 Torr

With copper(l) iodide; hydrogen; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; diethyl ether;

DOI:10.1021/ol070748n

upstream raw materials:

2-(3-(4-methoxybenzyloxy)prop-1-ynyl)-4,6-dimethylpyridine-3,5-dicarbonitrile

2-bromo-4,6-dimethyl-3,5-dicarbonitrile

2-methyl-4-oxo-3-(phenylamino)pent-2-enenitrile

C₉H₇N₃O

Downstream raw materials:

2-(3-(4-methoxybenzyloxy)propyl)-4,6-dimethylpyridine-3,5-dicarbaldehyde