8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one

Base Information

Chemical Name:8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one
CAS No.:188635-46-3
Molecular Formula:C₃₀H₃₀O₄
Molecular Weight:454.566
Hs Code.:

Synonyms:8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one

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Chemical Property of 8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one

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Technology Process of 8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one

There total 10 articles about 8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 67-56-1
methanol

: 1454588-41-0
5-methyl hydrogen 9-isopropyl-6-methyl-1-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptalene-4,5-dicarboxylate

: 188635-46-3
8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one

Guidance literature:: 5-methyl hydrogen 9-isopropyl-6-methyl-1-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptalene-4,5-dicarboxylate; With oxalyl dichloride; N,N-dimethyl-formamide; In acetonitrile; at 0 ℃;

methanol; In acetonitrile; at 20 ℃;
DOI:10.1002/hlca.201300137

Reference yield:

: 98525-07-6,72898-39-6,98525-12-3,98525-13-4
dimethyl 1,6-dimethyl-9-(1-methylethyl)heptalene-4,5-dicarboxylate

: 188635-46-3
8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / t-BuOK, C₂Cl₆ / tetrahydrofuran / -78 °C

2: NaI / acetone / 4 h / Ambient temperature

3: acetone / 4 h / Ambient temperature

4: 51 percent / 2N NaOH / CH₂Cl₂ / 72 h / Ambient temperature

5: 1.) LiOH; 2.) (COCl)2 / 1.) MeOH, H₂O, reflux, 1.5 h; 2.) DMF, MeCN, 0 deg C

With lithium hydroxide; sodium hydroxide; oxalyl dichloride; hexachloroethane; potassium tert-butylate; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1002/hlca.19970800123

Reference yield:

: 188635-39-4
dimethyl 1-(chloromethyl)-9-isopropyl-6-methylheptalene-4,5-dicarboxylate

: 188635-46-3
8-isopropyl-1,1-dimethoxy-11-methyl-6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]heptaleno[4,5-c]furan-3(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaI / acetone / 4 h / Ambient temperature

2: acetone / 4 h / Ambient temperature

3: 51 percent / 2N NaOH / CH₂Cl₂ / 72 h / Ambient temperature

4: 1.) LiOH; 2.) (COCl)2 / 1.) MeOH, H₂O, reflux, 1.5 h; 2.) DMF, MeCN, 0 deg C

With lithium hydroxide; sodium hydroxide; oxalyl dichloride; sodium iodide; In dichloromethane; acetone;
DOI:10.1002/hlca.19970800123