4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

Base Information

Chemical Name:4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid
CAS No.:1396723-08-2
Molecular Formula:C₂₀H₁₇ClN₂O₂
Molecular Weight:352.82
Hs Code.:

Synonyms:4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

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Chemical Property of 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

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Technology Process of 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

There total 6 articles about 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1396723-05-9
methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

: 1396723-08-2
4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

Guidance literature:: methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate; With water; potassium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 56525-63-4
methyl 3-chloro-4-methyl-benzoate

: 1396723-08-2
4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

2.1: toluene / 6 h / 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oill / 0.25 h / 0 °C

3.2: 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

5.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

5.2: 50 °C

6.1: potassium hydroxide; water / methanol / 20 °C

6.2: pH 5

With hydrogenchloride; N-Bromosuccinimide; water; sodium hydride; triethylamine; potassium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; paraffin oill; N,N-dimethyl-formamide; toluene;

Reference yield:

: 74733-30-5
methyl 4-Bromomethyl-3-chlorobenzoate

: 1396723-08-2
4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 6 h / 70 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oill / 0.25 h / 0 °C

2.2: 65 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

4.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

4.2: 50 °C

5.1: potassium hydroxide; water / methanol / 20 °C

5.2: pH 5

With hydrogenchloride; water; sodium hydride; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; paraffin oill; N,N-dimethyl-formamide; toluene;