N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

Base Information

Chemical Name:N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide
CAS No.:1609931-59-0
Molecular Formula:C₃₉H₅₀F₃N₃O₁₀
Molecular Weight:777.835
Hs Code.:

Synonyms:N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

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Chemical Property of N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

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Technology Process of N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

There total 2 articles about N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4246-51-9
4,7,10-trioxa-1,13-diaminotridecane

: 383-63-1
ethyl trifluoroacetate,

: 1397704-93-6
4-(2-(4,4' dimethoxytrityloxy)ethyl)morpholine 2,3 dione

: 1609931-59-0
N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

Guidance literature:: 4,7,10-trioxa-1,13-diaminotridecane; 4-(2-(4,4' dimethoxytrityloxy)ethyl)morpholine 2,3 dione; With pyridine; at 20 ℃; for 16h;

ethyl trifluoroacetate,; at 20 ℃; for 48h;
DOI:10.1021/ol500668n

Reference yield:

: 68898-62-4
N-(2-hydroxyethyl)morpholine-2,3-dione

: 1609931-59-0
N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 3 h / 20 °C

2.1: pyridine / 16 h / 20 °C

2.2: 48 h / 20 °C

With pyridine;
DOI:10.1021/ol500668n

Reference yield: 73.0%

: 1609931-59-0
N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1609931-60-3
N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyloxamide

Guidance literature:: N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite; With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.5h;

N-(13-trifluoroacetylamino-10,7,4-trioxatridecyl)-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyloxalamide; In acetonitrile; at 20 ℃; for 1.03333h;
DOI:10.1021/ol500668n