N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

Base Information

Chemical Name:N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine
CAS No.:134222-04-1
Molecular Formula:C₂₆H₂₂FN₅O₇
Molecular Weight:535.488
Hs Code.:

N<sup>2</sup>-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

Synonyms:N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

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Technology Process of N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

There total 4 articles about N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 127-09-3
sodium acetate

: 118373-61-8
2-amino-6-chloro-9-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-9H-purine

: 134222-04-1
N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

Guidance literature:: In acetic anhydride; acetic acid; at 120 - 125 ℃; for 2.5h;
DOI:10.1016/j.tetlet.2015.11.091

Reference yield:

: 97614-43-2
1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose

: 134222-04-1
N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc dibromide; trimethylsilyl bromide / dichloromethane / 20.17 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / 1,2-dimethoxyethane / 0.67 h / 20 °C

2.2: 18 h / 20 °C / Inert atmosphere

3.1: acetic anhydride; acetic acid / 2.5 h / 120 - 125 °C

With trimethylsilyl bromide; potassium tert-butylate; zinc dibromide; In 1,2-dimethoxyethane; dichloromethane; acetic anhydride; acetic acid;
DOI:10.1016/j.tetlet.2015.11.091

Reference yield:

: 97614-44-3
2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide

: 134222-04-1
N²-acetyl-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)guanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / 1,2-dimethoxyethane / 0.67 h / 20 °C

1.2: 18 h / 20 °C / Inert atmosphere

2.1: acetic anhydride; acetic acid / 2.5 h / 120 - 125 °C

With potassium tert-butylate; In 1,2-dimethoxyethane; acetic anhydride; acetic acid;
DOI:10.1016/j.tetlet.2015.11.091