(3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Base Information

Chemical Name:(3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide
CAS No.:1600507-33-2
Molecular Formula:C₁₂H₁₄BrFN₂O₂S
Molecular Weight:349.224
Hs Code.:

Synonyms:(3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Chemical Property:

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Technology Process of (3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

There total 6 articles about (3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1600507-33-2
(3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:

Reference yield:

: 1313525-80-2
rac-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-carbamic acid tert-butyl ester

: 1600507-33-2
(3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

2: sodium methylate / water; ethanol; methanol; dihydrogen peroxide; n-heptane

With sodium methylate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; n-heptane; water; dihydrogen peroxide;

Reference yield:

: 1600513-16-3
(R)-2-amino-2-(5-bromo-2-fluorophenyl)propan-1-ol HCl

: 1600507-33-2
(3R)-5-amino-3-(5-bromo-2-fluorophenyl)-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water

2: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

3: sodium methylate / water; ethanol; methanol; dihydrogen peroxide; n-heptane

With sodium methylate; sodium hydrogencarbonate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; water; dihydrogen peroxide;