(3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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Chemical Name:(3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide
CAS No.:1600508-33-5
Molecular Formula:C₂₀H₁₈ClF₂N₅O₂S
Molecular Weight:465.911
Hs Code.:

Synonyms:

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Chemical Property of (3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

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Technology Process of (3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

There total 10 articles about (3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1600511-49-6
tert-butyl ((2R,5R)-5-(5-amino-2-fluorophenyl)-2-fluoro-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)carbamate

: 1260672-65-8
3,8-dichloro-1,7-naphthyridine

: 1600508-33-5
(3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:

Reference yield:

: 1313525-80-2
rac-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-carbamic acid tert-butyl ester

: 1600508-33-5
(3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

2: sodium methylate / water; ethanol; methanol; dihydrogen peroxide; n-heptane

With sodium methylate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; n-heptane; water; dihydrogen peroxide;

Reference yield:

: 1600513-16-3
(R)-2-amino-2-(5-bromo-2-fluorophenyl)propan-1-ol HCl

: 1600508-33-5
(3R,6R)-5-Amino-3-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-6-fluoro-3,6-dimethyl-3,6-dihydro-2H-1,4-thiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water

2: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran

3: sodium methylate / water; ethanol; methanol; dihydrogen peroxide; n-heptane

With sodium methylate; sodium hydrogencarbonate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; water; dihydrogen peroxide;