N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

Base Information

Chemical Name:N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide
CAS No.:1307741-70-3
Molecular Formula:C₂₁H₁₈F₆INO₄
Molecular Weight:589.273
Hs Code.:

Synonyms:N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

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Chemical Property of N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

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Technology Process of N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

There total 5 articles about N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 609-67-6
2-Iodobenzoyl chloride

: 1307741-37-2
C₁₄H₁₅F₆NO₃

: 1307741-70-3
N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 849517-65-3
4-iodobenzo[d][1,3]dioxole

: 1307741-70-3
N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 15 h / 90 °C

2: toluene-4-sulfonic acid / toluene / 10 h / 120 °C / Molecular sieve

3: triethylamine / dichloromethane / 3 h / 0 °C

With copper(l) iodide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; L-proline; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 1307741-34-9
4-(butylamino)benzo[d][1,3]dioxole

: 1307741-70-3
N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 10 h / 120 °C / Molecular sieve

2: triethylamine / dichloromethane / 3 h / 0 °C

With toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.03.002