N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide

Base Information

Chemical Name:N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide
CAS No.:1314887-01-8
Molecular Formula:C₂₂H₂₃F₃N₄O₃S
Molecular Weight:480.511
Hs Code.:

Synonyms:N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide

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Technology Process of N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide

There total 7 articles about N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314887-00-7
5-amino-5-(hydroxyimino)-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)pentanamide

: 407-25-0
trifluoroacetic anhydride

: 1314887-01-8
N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide

Guidance literature:: With pyridine; at 0 - 110 ℃; for 3h;

Reference yield:

: 1314886-98-0
(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine

: 1314887-01-8
N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

2: hydroxylamine hydrochloride; sodium carbonate / 8-quinolinol / ethanol; water / 12 h / Reflux

3: pyridine / 3 h / 0 - 110 °C

With 4-methyl-morpholine; pyridine; hydroxylamine hydrochloride; sodium carbonate; HATU; 8-quinolinol; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1314886-99-1
4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

: 1314887-01-8
N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium carbonate / 8-quinolinol / ethanol; water / 12 h / Reflux

2: pyridine / 3 h / 0 - 110 °C

With pyridine; hydroxylamine hydrochloride; sodium carbonate; 8-quinolinol; In ethanol; water;