4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

Base Information

Chemical Name:4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide
CAS No.:1314886-99-1
Molecular Formula:C₂₀H₂₃N₃O₂S
Molecular Weight:369.488
Hs Code.:

Synonyms:4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

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Technology Process of 4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

There total 3 articles about 4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 39201-33-7
4-cyanobutyric acid

: 1314886-98-0
(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine

: 1314886-99-1
4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

Reference yield:

: 1314886-95-7
4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-carbonitrile

: 1314886-99-1
4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1314886-99-1
4-cyano-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 4 h / 80 °C / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; sodium hydride; HATU; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;