trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester

Base Information

Chemical Name:trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester
CAS No.:400899-57-2
Molecular Formula:C₁₇H₂₉NO₅S
Molecular Weight:359.487
Hs Code.:

Synonyms:trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester

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Chemical Property of trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester

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Technology Process of trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester

There total 2 articles about trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 400899-56-1
trans-[4-(4-hydroxy-but-1-ynyl)cyclohexyl]methylcarbamic acid tert-butyl ester

: 124-63-0
methanesulfonyl chloride

: 400899-57-2
trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm300256z

Reference yield:

: 400898-97-7
C₂₂H₃₇NO₄

: 400899-57-2
trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / methanol / 1.5 h / 55 °C / Inert atmosphere

2: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; pyridinium p-toluenesulfonate; In methanol; dichloromethane;
DOI:10.1021/jm300256z

Reference yield:

: 400899-57-2
trans-methanesulfonic acid 4-[4-(N-(tert-butoxycarbonyl)-N-methylamino)cyclohexyl]but-3-ynyl ester

: 1379455-53-4
trans-(4-{5-[ethyl-(2-hydroxyethyl)amino]pent-1-ynyl}-cyclohexyl)methylcarbamic acid 4-chlorophenyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

3: methanol / 65 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; water / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/jm300256z