Technology Process of N-(3,5-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine
There total 7 articles about N-(3,5-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; potassium carbonate; XPhos;
In
tert-butyl alcohol;
at 110 ℃;
for 3h;
DOI:10.1016/j.bmcl.2017.02.001
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diethyl ether / 20 °C
2.1: potassium carbonate / water / 20 °C / pH 9
3.1: 1,1,1,3,3,3-hexamethyl-disilazane / toluene / 1 h / 20 °C
4.1: sodium hydroxide / methanol; water / 16 h / 20 °C
5.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C
5.2: 3 h / 85 °C
6.1: palladium diacetate; potassium carbonate; XPhos / tert-butyl alcohol / 3 h / 110 °C
With
palladium diacetate; sodium hydride; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; XPhos;
In
tetrahydrofuran; methanol; diethyl ether; water; toluene; tert-butyl alcohol;
6.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2017.02.001