carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester

Base Information

• Chemical Name: carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester
• CAS No.: 477978-04-4
• Molecular Formula: C₃₂H₃₅N₃O₉
• Molecular Weight: 605.645

Synonyms:carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester

Chemical Property of carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester

Chemical Property:

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Technology Process of carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester

There total 2 articles about carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Orn(Boc)-OH (109425-55-0,118476-89-4) → carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester (477978-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h

1.2: 92 percent / aq. sodium borohydride / tetrahydrofuran / 1 h

2.1: 9.40 g / pyridine / tetrahydrofuran / 0.5 h

With pyridine; 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1021/ja0275109

Reference yield:

[4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-pentyl]-carbamic acid tert-butyl ester (544713-80-6) + 4-Nitrophenyl chloroformate (7693-46-1) → carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester (477978-04-4)

Guidance literature:

With pyridine; In tetrahydrofuran; for 0.5h;

DOI:10.1021/ja0275109

Reference yield: 78.0%

2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-thioureido-benzoic acid + carbonic acid 5-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentyl ester 4-nitro-phenyl ester (477978-04-4) + 6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid (88574-06-5) → C69H109N17O20S*7C2HF3O2

Guidance literature:

Multistep reaction.;

DOI:10.1021/ja0275109

upstream raw materials:

[4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-pentyl]-carbamic acid tert-butyl ester

4-Nitrophenyl chloroformate

Fmoc-Orn(Boc)-OH

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