182227-47-0

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 108-95-2 phenol 
• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 
• 929-59-9 3,6-dioxa-1,8-diaminooctane 
• 182227-50-5 {2-[2-(2-{2-[4-(Diethoxy-phosphoryloxy)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester 
• 182227-44-7 [2-(2-{2-[2-Hydroxy-2-(4-hydroxy-phenyl)-acetylamino]-ethoxy}-ethoxy)-ethyl]-carbamic acid tert-butyl ester 
• 1198-84-1 4-hydroxymandelic acid 

Downstream Products

• 570391-82-1 phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester 

Relevant academic research and scientific papers

Activity-based fluorescent probes that target phosphatases

We have successfully designed and synthesized two fluorescently-labeled, activity-based probes, Probe 1 and Probe 2, which were shown to label protein tyrosine phosphatases specifically, as well as other types of phosphatases. The probes were not reactive towards the other non-phosphatase enzymes tested. These probes may find potential applications in large-scale proteomic experiments whereby subclasses of proteins may be selectively identified.

A versatile mechanism based reaction probe for the direct selection of biocatalysts

A mechanism based reaction probe was synthesized and shown to modify a bacterial phosphotriesterase; this strategy for generating a probe is general and should allow the isolation of a host of unique catalysts.