(3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione

Base Information

Chemical Name:(3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione
CAS No.:652140-58-4
Molecular Formula:C₂₅H₃₀N₂O₄
Molecular Weight:424.508
Hs Code.:

Synonyms:(3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione

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Chemical Property of (3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione

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Technology Process of (3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione

There total 1 articles about (3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 23726-00-3
<²H9>trimethylsulphoxonium iodide

: 219916-54-8
(S)-N,N'-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2,5-dione

: 652140-58-4
(3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione

Guidance literature:: <²H9>trimethylsulphoxonium iodide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h;

(S)-N,N'-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2,5-dione; In tetrahydrofuran; hexane; at 20 ℃; Further stages.;
DOI:10.1039/b303348a

Reference yield:

: 67-56-1
methanol

: 652140-58-4
(3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione

: 6306-52-1
L-valine methylester hydrochloride

: (S)-1-amino-[2,2-2H]-cyclopropanecarboxylic acid methyl ester hydrochloride

Guidance literature:: (3S,6S)-4,7-bis(4-methoxybenzyl)-[1,1-2H]-6-isopropyl-4,7-diazaspiro[2.5]octane-5,8-dione; With hydrogenchloride; for 24h; Heating;

methanol; With thionyl chloride; Further stages. Title compound not separated from byproducts.; Heating;
DOI:10.1039/b303348a