3-Carboxy DetoMidine Methyl Ester

Base Information

Chemical Name:3-Carboxy DetoMidine Methyl Ester
CAS No.:146197-56-0
Molecular Formula:C₁₃H₁₄N₂O₂
Molecular Weight:230.266
Hs Code.:
Mol file:146197-56-0.mol

Synonyms:methyl 3-(4⁽⁵⁾-imidazolylmethyl)-2-methylbenzoate

Suppliers and Price of 3-Carboxy DetoMidine Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
3-Carboxy Detomidine Methyl Ester
5mg
$ 460.00

TRC
3-CarboxyDetomidineMethylEster
1mg
$ 165.00

Medical Isotopes, Inc.
3-CarboxyDetomidineMethylEster
50 mg
$ 2200.00

Medical Isotopes, Inc.
3-CarboxyDetomidineMethylEster
5 mg
$ 650.00

American Custom Chemicals Corporation
3-CARBOXY DETOMIDINE METHYL ESTER 95.00%
5MG
$ 498.96

Total 1 raw suppliers

Chemical Property of 3-Carboxy DetoMidine Methyl Ester

Chemical Property:

Purity/Quality:: 3-Carboxy Detomidine Methyl Ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-Carboxy Detomidine Methyl Ester is an intermediate used in the preparation of 3-Carboxy Detomidine (C177915), a major metabolite of the drug Detomidine.

Technology Process of 3-Carboxy DetoMidine Methyl Ester

There total 7 articles about 3-Carboxy DetoMidine Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133232-56-1
3-iodo-2-methylbenzoic acid

: 146197-56-0
methyl 3-(4⁽⁵⁾-imidazolylmethyl)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 54 percent / trimethyl borate, BH₃*Me₂S / tetrahydrofuran / 1.5 h / Ambient temperature

2: 86 percent / LiBr, p-TsOH / Ambient temperature

3: 1.) Mg, 1,2-dibromoethane / 1.) THF, reflux, 6.5 h, 2.) THF, RT, overnight

4: 90 percent / MnO₂ / CHCl₃ / 1 h / Heating

5: 51 percent / KOH, hydrazine hydrate / ethane-1,2-diol / 2 h / 200 °C

6: 58 percent / aq. HCl / 2.5 h / 110 - 120 °C

7: MnO₂ / tetrahydrofuran / 5 h / 40 - 50 °C

8: AcOH, NaCN, MnO₂ / Ambient temperature

With hydrogenchloride; manganese(IV) oxide; potassium hydroxide; Trimethyl borate; dimethylsulfide borane complex; sodium cyanide; toluene-4-sulfonic acid; hydrazine hydrate; magnesium; acetic acid; ethylene dibromide; lithium bromide; In tetrahydrofuran; chloroform; ethylene glycol;

Reference yield:

: 76350-89-5
(3-iodo-2-methylphenyl)methanol

: 146197-56-0
methyl 3-(4⁽⁵⁾-imidazolylmethyl)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / LiBr, p-TsOH / Ambient temperature

2: 1.) Mg, 1,2-dibromoethane / 1.) THF, reflux, 6.5 h, 2.) THF, RT, overnight

3: 90 percent / MnO₂ / CHCl₃ / 1 h / Heating

4: 51 percent / KOH, hydrazine hydrate / ethane-1,2-diol / 2 h / 200 °C

5: 58 percent / aq. HCl / 2.5 h / 110 - 120 °C

6: MnO₂ / tetrahydrofuran / 5 h / 40 - 50 °C

7: AcOH, NaCN, MnO₂ / Ambient temperature

With hydrogenchloride; manganese(IV) oxide; potassium hydroxide; sodium cyanide; toluene-4-sulfonic acid; hydrazine hydrate; magnesium; acetic acid; ethylene dibromide; lithium bromide; In tetrahydrofuran; chloroform; ethylene glycol;

Reference yield:

: 146197-51-5
3-iodo-2-methylbenzyl methoxymethyl ether

: 146197-56-0
methyl 3-(4⁽⁵⁾-imidazolylmethyl)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg, 1,2-dibromoethane / 1.) THF, reflux, 6.5 h, 2.) THF, RT, overnight

2: 90 percent / MnO₂ / CHCl₃ / 1 h / Heating

3: 51 percent / KOH, hydrazine hydrate / ethane-1,2-diol / 2 h / 200 °C

4: 58 percent / aq. HCl / 2.5 h / 110 - 120 °C

5: MnO₂ / tetrahydrofuran / 5 h / 40 - 50 °C

6: AcOH, NaCN, MnO₂ / Ambient temperature

With hydrogenchloride; manganese(IV) oxide; potassium hydroxide; sodium cyanide; hydrazine hydrate; magnesium; acetic acid; ethylene dibromide; In tetrahydrofuran; chloroform; ethylene glycol;