(7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate

Base Information

• Chemical Name: (7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate
• CAS No.: 1350907-96-8
• Molecular Formula: C₁₁H₉ClN₂O₃
• Molecular Weight: 252.657
• Mol file: 1350907-96-8.mol

Synonyms:(7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate

Chemical Property of (7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate

There total 4 articles about (7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(7-chloro-3-iodo-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate (1350907-95-7) + 4-methoxyphenylboronic acid (5720-07-0) → (7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate (1350907-96-8) + [7-chloro-3-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl]methyl acetate (1350907-97-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; ethanol; at 100 ℃; for 8h;

DOI:10.1055/s-0030-1260197

Reference yield:

5-chloro-2-pyridylamine (1072-98-6) → (7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate (1350907-96-8) + [7-chloro-3-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl]methyl acetate (1350907-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1: polyphosphoric acid / 3 h / 110 °C

2: N-iodo-succinimide / acetonitrile / 16 h / Reflux

3: N,N-dimethyl-formamide / 5 h / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol / 3 h / 80 °C / Microwave irradiation

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki coupling;

DOI:10.1055/s-0030-1260197

Reference yield:

7-chloro-2-(chloromethyl)-3-iodo-4H-pyrido[1,2-a]pyrimidin-4-one (817206-07-8) → (7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate (1350907-96-8) + [7-chloro-3-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl]methyl acetate (1350907-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol / 3 h / 80 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 2: Suzuki coupling;

DOI:10.1055/s-0030-1260197

upstream raw materials:

5-chloro-2-pyridylamine

7-chloro-2-(chloromethyl)-3-iodo-4H-pyrido[1,2-a]pyrimidin-4-one

(7-chloro-3-iodo-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl acetate

4-methoxyphenylboronic acid