8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Base Information

Chemical Name:8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester
CAS No.:229484-63-3
Molecular Formula:C₃₁H₂₇F₂N₅O₅
Molecular Weight:587.583
Hs Code.:

8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Synonyms:8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

There total 7 articles about 8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 103-67-3
benzyl-methyl-amine

: 229484-53-1
3-bromomethyl-8-(2,6-difluorobenzyl)-5,8-dihydro-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

: 229484-63-3
8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2007.04.065

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 229484-63-3
8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / K₂CO₃; KI / dimethylformamide

2: 89 percent / NaNO₃; conc. H₂SO₄

3: NBS; AIBN / CCl₄

4: i-Pr₂NEt / dimethylformamide

With sodium nitrate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00372-4

Reference yield:

: 15400-53-0
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

: 229484-63-3
8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 37 percent / K₂CO₃; KI / dimethylformamide

2: 78 percent / Zn; AcOH

3: 85 percent / K₂CO₃; KI / dimethylformamide

4: 89 percent / NaNO₃; conc. H₂SO₄

5: NBS; AIBN / CCl₄

6: i-Pr₂NEt / dimethylformamide

With sodium nitrate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; zinc; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00372-4