3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride

Base Information

Chemical Name:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride
CAS No.:1352610-35-5
Molecular Formula:C₂₃H₁₈N₈*ClH
Molecular Weight:442.91
Hs Code.:

Synonyms:3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride

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Chemical Property of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride

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Technology Process of 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride

There total 7 articles about 3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1352609-28-9
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile

: 1352610-35-5
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; isopropyl alcohol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: C₂₃H₁₆N₈

: 1352610-35-5
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; isopropyl alcohol / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 614750-82-2
1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone

: 1352610-35-5
3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methylamino)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen bromide; water / dimethyl sulfoxide / 2 h / 60 - 70 °C

2: ammonium acetate / methanol; tert-butyl methyl ether; water / 4 h / 20 °C

3: hydrogenchloride / water / 4 h / 70 °C

4: acetic acid / 1,2-dichloro-ethane / 2 h / 120 °C / Inert atmosphere; Sealed tube

5: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

6: hydrogenchloride / dichloromethane; isopropyl alcohol / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; ammonium acetate; water; hydrogen bromide; acetic acid; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; dimethyl sulfoxide; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2014.03.022