3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Chemical Name:3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester
CAS No.:1207172-99-3
Molecular Formula:C₂₂H₁₈N₂O₆S
Molecular Weight:438.461
Hs Code.:

Synonyms:3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Chemical Property of 3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Technology Process of 3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

There total 5 articles about 3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: C₂₄H₁₈N₂O₂S

: 2166-14-5
1,2,4,5-tetrazine-3,6-dicarboxylic acid dimethyl ester

: 1207172-99-3
3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

: C₃₀H₂₄N₄O₆S

: 1207172-98-2
C₃₀H₂₃N₃O₆S

Guidance literature:: C₂₄H₁₈N₂O₂S; 1,2,4,5-tetrazine-3,6-dicarboxylic acid dimethyl ester; In toluene; Reflux;

With zinc; In acetic acid;
DOI:10.1016/j.tetlet.2009.11.085

Reference yield:

: 67-56-1
methanol

: 3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid 5-methyl ester

: 1207172-99-3
3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: 3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid 5-methyl ester; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 40 ℃; for 1h; Inert atmosphere;

methanol; In N,N-dimethyl-formamide; at 40 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2014.11.035

Reference yield:

: 934-05-4
methyl 4-bromo-1H-pyrrole-2-carboxylate

: 1207172-99-3
3-(1-benzenesulfonyl-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / dichloromethane / 20 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol; water / 2 h / 110 °C / Microwave irradiation

3.1: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 40 °C / Inert atmosphere

4.2: 24 h / 40 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; sodium chlorite; sodium dihydrogenphosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-carbonyldiimidazole; trichlorophosphate; In ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2.1: |Suzuki Coupling;
DOI:10.1016/j.tet.2014.11.035