[3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester
• CAS No.: 173406-25-2
• Molecular Formula: C₂₆H₄₀N₄O₂
• Molecular Weight: 440.629
• Mol file: 173406-25-2.mol

Synonyms:[3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester

Chemical Property of [3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester

There total 9 articles about [3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

13-cyano-9,12-di(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12-triazotridecane (154920-42-0) → [3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester (173406-25-2)

Guidance literature:

With sodium hydroxide; hydrogen; nickel; In ethanol; for 12h; under 2327.2 Torr;

DOI:10.1002/jhet.5570300532

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → [3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester (173406-25-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 81 percent / tetrahydrofuran / 6 h / Ambient temperature

2: 87 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

3: 92 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

4: magnesium sulfate / methanol / 4 h / Ambient temperature

5: NaBH₄ / methanol / Ambient temperature

6: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

7: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

With potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; nickel; In tetrahydrofuran; methanol; ethanol; acetonitrile;

DOI:10.1002/jhet.5570300532

Reference yield:

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine (90914-08-2) → [3-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-propyl]-carbamic acid tert-butyl ester (173406-25-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 87 percent / potassium fluoride/celite / acetonitrile / 12 h / 85 °C

2: 92 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

3: magnesium sulfate / methanol / 4 h / Ambient temperature

4: NaBH₄ / methanol / Ambient temperature

5: 96 percent / KF/celite / acetonitrile / 12 h / 85 °C

6: 87 percent / H₂, aq. NaOH / Raney Ni / ethanol / 12 h / 2327.2 Torr

With potassium fluoride; sodium hydroxide; sodium tetrahydroborate; Celite; hydrogen; magnesium sulfate; nickel; In methanol; ethanol; acetonitrile;

DOI:10.1002/jhet.5570300532

upstream raw materials:

13-cyano-9,12-di(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12-triazotridecane

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

N-[N-(tert-Butyloxycarbonyl)-3-aminopropyl]benzylamine

benzaldehyde

Downstream raw materials:

9,12,15-tri(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12,15-tetraazapentadecane

13-amino-1,4,7,10-tetra(phenylmethyl)-1,4,7,10-tetraazatridecane

(3-{[2-({2-[(2-Amino-ethyl)-benzyl-amino]-ethyl}-benzyl-amino)-ethyl]-benzyl-amino}-propyl)-carbamic acid tert-butyl ester

16-cyano-9,12,15-tri(phenylmethyl)-2,2-dimethyl-3-oxa-4-oxo-5,9,12,15-tetraazahexadecane