Z-TYR(TBU)-OET

Base Information

Chemical Name:Z-TYR(TBU)-OET
CAS No.:66328-78-7
Molecular Formula:C23H29 N O5
Molecular Weight:399.487
Hs Code.:
Mol file:66328-78-7.mol

Synonyms:Alanine, 3-(p-tert-butoxyphenyl)-N-carboxy-, N-benzyl ethyl ester (7CI)

Suppliers and Price of Z-TYR(TBU)-OET

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Z-TYR(TBU)-OET

Chemical Property:

PSA：73.86000
LogP:4.65540

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Z-TYR(TBU)-OET

There total 1 articles about Z-TYR(TBU)-OET which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16679-94-0
N-[(phenylmethoxy)carbonyl]-L-tyrosine

: 115-11-7,15220-85-6
isobutene

: 66328-78-7
N-(benzyloxycarbonyl)-O-tert-butyltyrosine ethyl ester

Guidance literature:: With sulfuric acid; In dichloromethane;

Reference yield: 89.7%

: 66328-78-7
N-(benzyloxycarbonyl)-O-tert-butyltyrosine ethyl ester

: 5545-54-0
N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/jm00390a005

Reference yield:

: 66328-78-7
N-(benzyloxycarbonyl)-O-tert-butyltyrosine ethyl ester

: 107941-77-5
(N,N-dipropyl,Leu⁵)enkephalin

Guidance literature:: Multi-step reaction with 8 steps

1: 89.7 percent / 0.25 N NaOH / tetrahydrofuran / 25 °C

2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF

3: 80.7 percent / 0.25 N NaOH / tetrahydrofuran

4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, 2.) THF, DMF

5: 91.9 percent / ammonium formate, H₂ / 10percent Pd/C / methanol / 0.67 h

6: 43.3 percent / N,N-diisopropylethylamine / toluene / 6.5 h / Heating

7: 78.7 percent / 0.25 N NaOH / tetrahydrofuran / 7.5 h / 25 °C

8: 68.4 percent / 50percent CF₃COOH, 10percent anisole / CH₂Cl₂ / 2.5 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; ammonium formate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00390a005