Ethyl 3,6-dihydro-2,6-dioxo-4-phenyl-1(2H)-pyrimidineacetate

Base Information

Chemical Name:Ethyl 3,6-dihydro-2,6-dioxo-4-phenyl-1(2H)-pyrimidineacetate
CAS No.:61736-37-6
Molecular Formula:C₁₄H₁₄N₂O₄
Molecular Weight:274.276
Hs Code.:
DSSTox Substance ID:DTXSID801186275

Synonyms:DTXSID801186275;Ethyl 3,6-dihydro-2,6-dioxo-4-phenyl-1(2H)-pyrimidineacetate;61736-37-6

Suppliers and Price of Ethyl 3,6-dihydro-2,6-dioxo-4-phenyl-1(2H)-pyrimidineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ethyl 3,6-dihydro-2,6-dioxo-4-phenyl-1(2H)-pyrimidineacetate

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:274.09535693
Heavy Atom Count:20
Complexity:439

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CN1C(=O)C=C(NC1=O)C2=CC=CC=C2

Technology Process of Ethyl 3,6-dihydro-2,6-dioxo-4-phenyl-1(2H)-pyrimidineacetate

There total 4 articles about Ethyl 3,6-dihydro-2,6-dioxo-4-phenyl-1(2H)-pyrimidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2999-46-4
Ethyl isocyanoacetate

: 1076-59-1
3-phenyl-4H-isoxazol-5-one

: 61736-37-6
ethyl 2-(2,6-dioxo-4-phenyl-2,3-dihydropyrimidin-1(6H)-yl)acetate

Guidance literature:: With pyridine; silver(l) oxide; In 1,4-dioxane; at 80 ℃; for 6h; Inert atmosphere; Sealed tube; Industrial scale;

Reference yield:

: 13345-09-0
6-phenyluracil

: 61736-37-6
ethyl 2-(2,6-dioxo-4-phenyl-2,3-dihydropyrimidin-1(6H)-yl)acetate

Guidance literature:: With sodium ethanolate; anschliessend mit Chloressigsaeure-aethylester;
DOI:10.1021/ja01375a051

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 61736-37-6
ethyl 2-(2,6-dioxo-4-phenyl-2,3-dihydropyrimidin-1(6H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; hydroxylamine hydrochloride / ethanol / 16 h / 60 °C

2: silver(l) oxide; pyridine / 1,4-dioxane / 6 h / 80 °C / Schlenk technique; Inert atmosphere; Sealed tube

With pyridine; hydroxylamine hydrochloride; silver(l) oxide; In 1,4-dioxane; ethanol;
DOI:10.1002/anie.201801363