N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine

Base Information

Chemical Name:N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine
CAS No.:1344720-58-6
Molecular Formula:C₁₉H₂₈BrNO₅
Molecular Weight:430.339
Hs Code.:

Synonyms:N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine

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Technology Process of N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine

There total 4 articles about N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1344720-62-2
2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxy-phenyl-acetonitrile

: 1344720-58-6
N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine

Guidance literature:: With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2011.09.033

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1344720-58-6
N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; dichloromethane;
DOI:10.1016/j.tet.2011.09.033

Reference yield:

: 222622-91-5
4-bromo-5-bromomethyl-2-methoxyphenol

: 1344720-58-6
N-Boc-N-[2-(2-bromo-5-(2,2-dimethylpropanoyloxy)-4-methoxyphenyl)ethyl]amine

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2: pyridine; dmap / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2011.09.033