2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

Base Information

Chemical Name:2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide
CAS No.:1268265-97-9
Molecular Formula:C₂₁H₂₈N₂O₂SSi
Molecular Weight:400.617
Hs Code.:

Synonyms:2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

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Chemical Property of 2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

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Technology Process of 2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

There total 2 articles about 2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98623-16-6
2-(4-amino-phenyl)ethanesulfonic acid methylamide

: 1268265-97-9
2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C

2.1: methanol / 25 - 30 °C

2.2: 4 h / 25 - 30 °C

3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C

3.2: 25 °C

With copper(l) iodide; iodine; sodium hydrogencarbonate; lithium chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 3.2: Sonogashira Coupling;

Reference yield:

: 1200070-42-3
2-(4-amino-3-iodo-phenyl)ethanesulfonic acid methylamide

: 1268265-97-9
2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 25 - 30 °C

1.2: 4 h / 25 - 30 °C

2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C

2.2: 25 °C

With copper(l) iodide; lithium chloride; In methanol; N,N-dimethyl-formamide; 2.2: Sonogashira Coupling;

Reference yield:

: 1268265-97-9
2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

: 121679-13-8
naratriptan

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; ethanol / 15 - 25 °C

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C

3.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C

4.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C

4.2: 25 - 30 °C

4.3: 10 - 15 °C

5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr

5.2: 10 °C / pH 7.5 - 8.5

With ethanol; potassium tert-butylate; hydrogen; acetic acid; trifluoroacetic acid; potassium hydroxide; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; 3.1: Aldol Condensation;