(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one

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Chemical Name:(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one
CAS No.:102045-99-8
Molecular Formula:C₂₅H₄₃NO₂Si₂
Molecular Weight:445.793
Hs Code.:

Synonyms:(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one

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Chemical Property of (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one

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Technology Process of (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one

There total 4 articles about (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 96735-59-0,96789-99-0,96790-00-0,96790-01-1,96790-03-3,96790-04-4,96790-05-5,96790-06-6,105087-57-8,121960-55-2
(S)-3-((R)-1-Hydroxy-ethyl)-4-((E)-styryl)-azetidin-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 96735-61-4,96790-07-7,96790-08-8,96790-09-9,102045-99-8,102046-00-4,105088-11-7
(S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one

Guidance literature:: With dmap; In dichloromethane;
DOI:10.1016/S0040-4039(00)61969-X

Reference yield:

: 83948-28-1
N-(trimethylsilyl)cinnamaldimine

: 96735-61-4,96790-07-7,96790-08-8,96790-09-9,102045-99-8,102046-00-4,105088-11-7
(S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / Lithium bis(trimethylsilyl)amide / tetrahydrofuran / 12 h / -78 - 20 °C / LDA_. 4S/4R ratio 7/3

2: Ph₃P, diethylazodicarboxylate

3: H₂O, OH^(1-)

4: 90 percent / DMAP / CH₂Cl₂

With dmap; water; hydroxide; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)61969-X

Reference yield:

: 96735-60-3,96790-02-2,96790-12-4,96790-13-5
Formic acid (R)-1-[(S)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-ethyl ester

: 96735-61-4,96790-07-7,96790-08-8,96790-09-9,102045-99-8,102046-00-4,105088-11-7
(S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((E)-styryl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O, OH^(1-)

2: 90 percent / DMAP / CH₂Cl₂

With dmap; water; hydroxide; In dichloromethane;
DOI:10.1016/S0040-4039(00)61969-X