Technology Process of 2,2-difluoro-2-(2-fluorophenyl)-ethylsulfamide
There total 6 articles about 2,2-difluoro-2-(2-fluorophenyl)-ethylsulfamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,2-difluoro-2-(2-fluorophenyl)-ethylamine;
With
pyridine; isocyanate de chlorosulfonyle; tert-butyl alcohol;
In
dichloromethane;
at 3 - 20 ℃;
for 5.08333h;
With
hydrogenchloride;
In
1,4-dioxane; ethyl acetate;
for 16h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h
2.1: pyridine; tert-butyl alcohol; isocyanate de chlorosulfonyle / dichloromethane / 5.08 h / 3 - 20 °C
2.2: 16 h
With
pyridine; isocyanate de chlorosulfonyle; hydrogen; tert-butyl alcohol;
palladium 10% on activated carbon;
In
dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 16 h / 70 °C
2.1: ethanol; sodium tetrahydroborate / 0 - 20 °C
3.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 1 h / -70 - 20 °C
3.2: 2 h / 60 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h
5.1: pyridine; tert-butyl alcohol; isocyanate de chlorosulfonyle / dichloromethane / 5.08 h / 3 - 20 °C
5.2: 16 h
With
pyridine; sodium tetrahydroborate; isocyanate de chlorosulfonyle; ethanol; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; tert-butyl alcohol;
palladium 10% on activated carbon;
In
dichloromethane; ethyl acetate; toluene;
