1813-93-0

Basic information

• Product Name: ETHYL 2-FLUOROBENZOYLFORMATE
• Synonyms: ETHYL 2-FLUOROBENZOYLFORMATE;ethyl 2-(2-fluorophenyl)-2-oxoacetate;2-Fluoro-oxo-benzeneacetic acid ethyl ester
• CAS NO: 1813-93-0
• Molecular Formula: C₁₀H₉FO₃
• Molecular Weight: 196.18
• Mol File: 1813-93-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 271.2°C at 760 mmHg
• Flash Point: 114.3°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 0.00654mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHYL 2-FLUOROBENZOYLFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-FLUOROBENZOYLFORMATE(1813-93-0)
• EPA Substance Registry System: ETHYL 2-FLUOROBENZOYLFORMATE(1813-93-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1813-93-0(Hazardous Substances Data)

Usage

General Description

Ethyl 2-Fluorobenzoate, also known as ETHYL 2-FLUOROBENZOYLFORMATE, is an organic compound with the molecular formula C9H8FNO2. It's a synthetic chemical that's used in the formulation of different chemical products. ETHYL 2-FLUOROBENZOYLFORMATE belongs to the family of benzoic acids and derivatives. Its physical properties indicate a white crystalline powder or colorless liquid form. As it's a specialized chemical, it's primarily used in research and development settings or in various industrial applications. Given its reactive nature, it should be handled with care, following safety guidelines to prevent unnecessary exposure.

InChI:InChI=1/C10H9FO3/c1-2-14-10(13)9(12)7-5-3-4-6-8(7)11/h3-6H,2H2,1H3

Upstream product

• 1240912-19-9 ethyl 2-diazo-3-(2-fluorophenyl)-3-oxopropanoate 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 4755-77-5 Ethyl oxalyl chloride 
• 1072-85-1 o-fluorobromobenzene 
• 95-92-1 oxalic acid diethyl ester 
• 109-72-8 n-butyllithium 
• 75716-82-4 imidazol-1-yl-oxo-acetic acid ethyl ester 
• 446-52-6 2-Fluorobenzaldehyde 
• 64-17-5 ethanol 
• 389-31-1 2-fluoromandelic acid 

Downstream Products

• 847866-70-0 3-(2-fluorophenyl)-3-hydroxy-5-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one 
• 698378-76-6 ethyl α,α-difluoro-α-(o-fluorophenyl)acetate 
• 1380202-32-3 2,2-difluoro-2-(2-fluoro-phenyl)-ethanol 
• 1380202-34-5 1-(2-azido-1,1-difluoroethyl)-2-fluorobenzene 
• 1380202-36-7 2,2-difluoro-2-(2-fluorophenyl)-ethylamine 
• 1380201-88-6 2,2-difluoro-2-(2-fluorophenyl)-ethylsulfamide 
• 1053246-11-9 (S)-1-(2-fluorophenyl)-1-(4-fluorophenyl)ethane-1,2-diol 
• 1053246-13-1 (S)-2-(2-fluorophenyl)-2-(4-fluorophenyl)oxirane 
• 586965-70-0 (S)-(+)-flutriafol 
• 1642594-38-4 C₁₈H₁₇FO₄ 
• 1596278-73-7 (S)-iso-propyl α-hydroxy-α-(2-flurophenyl)acetate 
• 1596279-14-9 isopropyl-2-(2-fluorophenyl)-2-oxoacetate 

Relevant articles and documents

Copper(I)-catalyzed aerobic oxidation of α-diazoesters

A practical Cu-catalyzed oxidation of α-diazoesters to α-ketoesters using molecular oxygen as an oxidant has been developed. Both electron-poor and electron-rich aryl α-diazoesters are suitable substrates and provide the α-ketoesters in good yields. In this oxidative system, α-diazo-β-ketoesters are also compatible as substrates but unexpectedly furnish α-ketoesters via C-C bond cleavage, rather than the vicinal tricarbonyl products.

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

NOVEL FLUORINATED SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention include fluorinated sulfamide derivatives having a disease-modifying action in the treatment of diseases associated with excitotoxicity and accompanying oxidative stress that include epilepsy, Alzheimer's disea