Technology Process of 2,2-difluoro-2-(2-fluorophenyl)-ethylamine
There total 5 articles about 2,2-difluoro-2-(2-fluorophenyl)-ethylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethyl acetate;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 16 h / 70 °C
2.1: ethanol; sodium tetrahydroborate / 0 - 20 °C
3.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 1 h / -70 - 20 °C
3.2: 2 h / 60 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h
With
sodium tetrahydroborate; ethanol; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
palladium 10% on activated carbon;
In
dichloromethane; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -70 °C / Inert atmosphere
1.2: -70 - 20 °C
2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 16 h / 70 °C
3.1: ethanol; sodium tetrahydroborate / 0 - 20 °C
4.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 1 h / -70 - 20 °C
4.2: 2 h / 60 °C
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h
With
sodium tetrahydroborate; n-butyllithium; ethanol; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
palladium 10% on activated carbon;
In
tetrahydrofuran; hexane; dichloromethane; ethyl acetate; toluene;