N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Base Information

Chemical Name:N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide
CAS No.:1374137-91-3
Molecular Formula:C₃₅H₃₈F₄N₄O₆S₂
Molecular Weight:750.836
Hs Code.:

N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Synonyms:N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Chemical Property of N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

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Technology Process of N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

There total 5 articles about N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-34-7
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

: 1374137-91-3
N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine; With 4-methyl-morpholine; isobutyl chloroformate; In 1,2-dimethoxyethane; at -15 ℃; for 0.5h;

With sodium tetrahydroborate; water; In 1,2-dimethoxyethane; at -50 ℃;

Reference yield:

: 1374138-31-4
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-5,5-difluoro-L-lysinate

: 1374137-91-3
N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dmap / 85 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: pH 4 / Sodium phosphate buffer

4.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / 0.5 h / -15 °C

4.2: -50 °C

With 4-methyl-morpholine; pyridine; methanol; di-isopropyl azodicarboxylate; triphenylphosphine; lithium hydroxide; isobutyl chloroformate; dmap; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 181124-40-3
1,3-benzothiazole-6-sulfonyl chloride

: 1374137-91-3
N-[(5S)-5-{(1,3-benzothiazol-6-ylsulfonyl)[(3,3-difluorocyclobutyl)methyl]amino}-2,2-difluoro-6-hydroxyhexyl]-Nα-(methoxycarbonyl)-β-phenyl-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dmap / 85 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: pH 4 / Sodium phosphate buffer

4.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / 0.5 h / -15 °C

4.2: -50 °C

With 4-methyl-morpholine; pyridine; methanol; di-isopropyl azodicarboxylate; triphenylphosphine; lithium hydroxide; isobutyl chloroformate; dmap; In tetrahydrofuran; 1,2-dimethoxyethane;