methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

Base Information

Chemical Name:methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate
CAS No.:1374138-32-5
Molecular Formula:C₃₁H₃₂F₂N₄O₇S₂
Molecular Weight:674.746
Hs Code.:

Synonyms:methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

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Chemical Property of methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

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Technology Process of methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

There total 1 articles about methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-31-4
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-5,5-difluoro-L-lysinate

: 181124-40-3
1,3-benzothiazole-6-sulfonyl chloride

: 1374138-32-5
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

Guidance literature:: With pyridine; dmap; at 85 ℃;

Reference yield:

: 681128-39-2
(3,3-difluorocyclobutyl)methanol

: 1374138-32-5
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

: 1374138-33-6
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 1374138-32-5
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

: 1374138-34-7
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 0 - 20 °C

2.2: pH 4 / Sodium phosphate buffer

With methanol; di-isopropyl azodicarboxylate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran;