methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

Base Information

Chemical Name:methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate
CAS No.:1374138-33-6
Molecular Formula:C₃₆H₃₈F₄N₄O₇S₂
Molecular Weight:778.846
Hs Code.:

methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

Synonyms:methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

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Chemical Property of methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

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Technology Process of methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

There total 3 articles about methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 681128-39-2
(3,3-difluorocyclobutyl)methanol

: 1374138-32-5
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-5,5-difluoro-L-lysinate

: 1374138-33-6
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 1374138-31-4
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-5,5-difluoro-L-lysinate

: 1374138-33-6
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dmap / 85 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With pyridine; di-isopropyl azodicarboxylate; triphenylphosphine; dmap; In tetrahydrofuran;

Reference yield:

: 181124-40-3
1,3-benzothiazole-6-sulfonyl chloride

: 1374138-33-6
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dmap / 85 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

With pyridine; di-isopropyl azodicarboxylate; triphenylphosphine; dmap; In tetrahydrofuran;