N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Base Information

Chemical Name:N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine
CAS No.:1374138-34-7
Molecular Formula:C₃₅H₃₆F₄N₄O₇S₂
Molecular Weight:764.819
Hs Code.:

Synonyms:N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Suppliers and Price of N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

There total 4 articles about N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-33-6
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate

: 1374138-34-7
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Guidance literature:: methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinate; With methanol; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

pH=4; Sodium phosphate buffer;

Reference yield:

: 1374138-31-4
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-5,5-difluoro-L-lysinate

: 1374138-34-7
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dmap / 85 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: pH 4 / Sodium phosphate buffer

With pyridine; methanol; di-isopropyl azodicarboxylate; triphenylphosphine; lithium hydroxide; dmap; In tetrahydrofuran;

Reference yield:

: 181124-40-3
1,3-benzothiazole-6-sulfonyl chloride

: 1374138-34-7
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dmap / 85 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: pH 4 / Sodium phosphate buffer

With pyridine; methanol; di-isopropyl azodicarboxylate; triphenylphosphine; lithium hydroxide; dmap; In tetrahydrofuran;