(R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Base Information

Chemical Name:(R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide
CAS No.:1223498-51-8
Molecular Formula:C₂₇H₂₆F₆N₄O₄S
Molecular Weight:616.584
Hs Code.:

(R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Synonyms:(R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

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Chemical Property of (R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

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Technology Process of (R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

There total 8 articles about (R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1223498-50-7
4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-(trifluoromethyl)pyrimidine

: 1223498-44-9
(R,S)-S-(4-aminophenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

: 1223498-51-8
(R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: 4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-(trifluoromethyl)pyrimidine; (R,S)-S-(4-aminophenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide; With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 80 ℃; for 5h;

With sodium hydrogencarbonate; In 1,4-dioxane; ethyl acetate; acetonitrile;

Reference yield:

: 851008-48-5
1-(cyclopropylsulphanyl)-4-nitrobenzene

: 1223498-51-8
(R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: Multi-step reaction with 4 steps

1: periodic acid / iron(III) chloride / acetonitrile / 0.5 h / 25 °C

2: magnesium oxide; [bis(acetoxy)iodo]benzene / dirhodium tetraacetate / dichloromethane / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 6.25 h / 25 °C / 760.05 Torr

4: hydrogenchloride / 1,4-dioxane; acetonitrile / 5 h / 80 °C

With hydrogenchloride; [bis(acetoxy)iodo]benzene; hydrogen; magnesium oxide; periodic acid; iron(III) chloride; dirhodium tetraacetate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 851008-45-2
(R,S)-1-(cyclopropylsulfinyl)-4-nitrobenzene

: 1223498-51-8
(R,S)-S-(4-{[4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulfoximide

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium oxide; [bis(acetoxy)iodo]benzene / dirhodium tetraacetate / dichloromethane / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 6.25 h / 25 °C / 760.05 Torr

3: hydrogenchloride / 1,4-dioxane; acetonitrile / 5 h / 80 °C

With hydrogenchloride; [bis(acetoxy)iodo]benzene; hydrogen; magnesium oxide; dirhodium tetraacetate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile;