Ethanone, 1-(2-methoxy-3-pyridinyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(2-methoxy-3-pyridinyl)- (9CI)
• CAS No.: 131674-40-3
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• Mol file: 131674-40-3.mol

Synonyms:Ethanone, 1-(2-methoxy-3-pyridinyl)- (9CI);3-Acetyl-2-methoxypyridine

Chemical Property of Ethanone, 1-(2-methoxy-3-pyridinyl)- (9CI)

Chemical Property:

• Boiling Point: 62℃ (9 Torr)
• PKA: 1.60±0.10(Predicted)
• PSA: 39.19000
• Density: 1.093±0.06 g/cm3(Predicted)
• LogP: 1.29280
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

1-(2-Methoxypyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(2-methoxy-3-pyridinyl)- (9CI)

There total 6 articles about Ethanone, 1-(2-methoxy-3-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3-acetyl-2-chloropyridine (55676-21-6) + sodium methylate (124-41-4) → 1-(2-methoxypyridin-3-yl)ethanone (131674-40-3)

Guidance literature:

In methanol; for 4h; Inert atmosphere;

DOI:10.1016/j.bmc.2015.07.056

Reference yield:

N,2-dimethoxy-N-methylnicotinamide (926003-56-7) + methylmagnesium bromide (75-16-1) → 1-(2-methoxypyridin-3-yl)ethanone (131674-40-3)

Guidance literature:

N,2-dimethoxy-N-methylnicotinamide; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; for 1.5h; Cooling with ice;

With ammonium chloride; In tetrahydrofuran; diethyl ether; ethyl acetate;

Reference yield:

2-methoxynicotinic acid (16498-81-0) → 1-(2-methoxypyridin-3-yl)ethanone (131674-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 6 h / Cooling with ice

1.2: 20 °C

2.1: diethyl ether; tetrahydrofuran / 1.5 h / Cooling with ice

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; chloroform;

upstream raw materials:

3-acetyl-2-chloropyridine

sodium methylate

methanol

pyridocyclobuten-5-one

Downstream raw materials:

3-(2-bromoacetyl)pyridin-2(1H)-one

Refernces

• 1、 -. "FUNCTIONALIZED HETROARYL ENONES EXHIBITING NRF2 ACTIVATION AND THEIR METHOD OF USE". Paragraph 0218. . Retrieved 2016/01/22.
• 2、 -. "10A-AZALIDE COMPOUND HAVING 4-MEMBERED RING STRUCTURE". . . Retrieved 2011/04/14.