4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid

Base Information

Chemical Name:4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid
CAS No.:1614251-43-2
Molecular Formula:C₁₉H₁₈N₄O₄
Molecular Weight:366.376
Hs Code.:

Synonyms:4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid

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Chemical Property of 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid

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Technology Process of 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid

There total 7 articles about 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1614251-42-1
methyl 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoate

: 1614251-43-2
4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid

Guidance literature:: methyl 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 1613623-81-6
1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

: 1614251-43-2
4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

4.2: pH 1

With tetrabutyl ammonium fluoride; water; potassium carbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; acetic acid butyl ester; water; N,N-dimethyl-formamide;

Reference yield:

: 1613623-83-8
3-(1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

: 1614251-43-2
4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

3.2: pH 1

With tetrabutyl ammonium fluoride; water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;