5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

Base Information

Chemical Name:5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid
CAS No.:1312009-36-1
Molecular Formula:C₂₃H₂₃ClN₄O₄
Molecular Weight:454.913
Hs Code.:

Synonyms:5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

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Chemical Property of 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

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Technology Process of 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

There total 16 articles about 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312009-00-9
methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

: 1312009-36-1
5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

Guidance literature:: methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate; With water; sodium hydroxide; In ethanol; at 65 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1312009-36-1
5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidic conditions

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

4.1: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 6 h / 65 °C / Inert atmosphere

With oxalyl dichloride; water; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1312009-36-1
5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

4: sodium hydroxide; water / ethanol / 6 h / 65 °C / Inert atmosphere

With oxalyl dichloride; water; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;