methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

Base Information

Chemical Name:methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate
CAS No.:1312009-00-9
Molecular Formula:C₂₄H₂₅ClN₄O₄
Molecular Weight:468.94
Hs Code.:

Synonyms:methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

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Chemical Property of methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

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Technology Process of methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

There total 14 articles about methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5454-83-1
5-bromovaleric acid methyl ester

: 1312008-98-2
4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazole

: 1312009-00-9
methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

: 1312008-99-3
methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]pentanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1312009-00-9
methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2.1: sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidic conditions

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

4.1: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With oxalyl dichloride; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1312009-00-9
methyl 5-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2H-indazol-2-yl]pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: triethylamine / acetonitrile / 0 °C / Inert atmosphere; Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;