(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

Base Information

Chemical Name:(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt
CAS No.:414869-73-1
Molecular Formula:C₆H₁₃N*C₂₄H₂₈O₄
Molecular Weight:479.66
Hs Code.:

Synonyms:(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

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Chemical Property of (E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

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Technology Process of (E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

There total 7 articles about (E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348622-94-6
3-(diethoxyphosphoryl)succinic acid 1-tert-butyl ester

: 414869-73-1
(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5 h / -5 - 0 °C / Inert atmosphere

2: ethyl acetate / 18 h / 20 - 40 °C / Cooling

With potassium tert-butylate; In tetrahydrofuran; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/op034001y

Reference yield:

: C₁₆H₁₆O

: 414869-73-1
(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

Guidance literature:: Multi-step reaction with 3 steps

1: sodium disulfite / water; methanol / 16.17 h / 20 °C

2: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5 h / -5 - 0 °C / Inert atmosphere

3: ethyl acetate / 18 h / 20 - 40 °C / Cooling

With sodium disulfite; potassium tert-butylate; In tetrahydrofuran; methanol; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/op034001y

Reference yield:

: 116632-39-4
2-methyl-4-bromoiodobenzene

: 414869-73-1
(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; triphenylphosphine; sodium carbonate / water; acetone / 12 h / Inert atmosphere; Reflux

2: palladium diacetate; tris-(o-tolyl)phosphine; sodium hydrogencarbonate; tetrabutyl-ammonium chloride / acetonitrile / 1 h / Inert atmosphere; Reflux

3: sodium disulfite / water; methanol / 16.17 h / 20 °C

4: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5 h / -5 - 0 °C / Inert atmosphere

5: ethyl acetate / 18 h / 20 - 40 °C / Cooling

With sodium disulfite; potassium tert-butylate; tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; sodium carbonate; triphenylphosphine; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; water; ethyl acetate; acetone; acetonitrile; tert-butyl alcohol; 1: |Suzuki Coupling;
DOI:10.1021/op034001y