(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

Base Information

Chemical Name:(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt
CAS No.:414869-76-4
Molecular Formula:C₆H₁₃N*C₂₄H₃₀O₄
Molecular Weight:481.676
Hs Code.:

Synonyms:(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

Suppliers and Price of (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

There total 9 articles about (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: [(S)-2,2'-bis(diphenylphosphino-1,1'-binaphthyl]chloro(p-cymene)ruthenium chloride

: 414869-73-1
(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

: 108-91-8,157973-60-9
cyclohexylamine

: 565-80-0
2,4-dimethylpentan-3-one

: 414869-76-4
(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

Guidance literature:: With citric acid; In methanol; water; ethyl acetate;

Reference yield: 65.0%

: 414869-73-1
(E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt

: 108-91-8,157973-60-9
cyclohexylamine

: 414869-76-4
(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

Guidance literature:: (E)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-2-pentenoic acid cyclohexylammonium salt; With ((-)-(1S)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; hydrogen; In methanol; at 60 ℃; for 40h; under 3102.97 Torr;

cyclohexylamine; In butanone; at 20 - 40 ℃; for 16h;
DOI:10.1021/op034001y

Reference yield:

: 77924-28-8
4-tert-butyl 1-ethyl 2-(diethoxyphosphoryl)succinate

: 414869-76-4
(R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)pentanoic acid cyclohexylammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran; ethanol; water / 18 h / -10 - 0 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5 h / -5 - 0 °C / Inert atmosphere

3.1: ethyl acetate / 18 h / 20 - 40 °C / Cooling

4.1: ((-)-(1S)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; hydrogen / methanol / 40 h / 60 °C / 3102.97 Torr

4.2: 16 h / 20 - 40 °C

With ((-)-(1S)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; potassium tert-butylate; hydrogen; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/op034001y