210891-12-6Relevant articles and documents
Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4- (2-oxazolyl)[1,1′-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ETA s
Murugesan, Natesan,Gu, Zhengxiang,Spergel, Steven,Young, Marian,Chen, Ping,Mathur, Arvind,Leith, Leslie,Hermsmeier, Mark,Liu, Eddie C.-K.,Zhang, Rongan,Bird, Eileen,Waldron, Tom,Marino, Anthony,Koplowitz, Barry,Humphreys, W. Griffith,Chong, Saeho,Morrison, Richard A.,Webb, Maria L.,Moreland, Suzanne,Trippodo, Nick,Barrish, Joel C.
, p. 125 - 137 (2007/10/03)
We have previously disclosed the selective ETA receptor antagonist N-(3,4-dimethyl-5-isoxazolyl)-4′-(2-oxazolyl)[1,1′- biphenyl]-2-sulfonamide (1, BMS-193884) as a clinical development candidate. Additional SAR studies at the 2′-position of 1 l
Methods for the preparation of biphenyl isoxazole sulfonamides
-
, (2008/06/13)
Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endo