2-Bromo-5-phenylpyridine

Base Information

• Chemical Name: 2-Bromo-5-phenylpyridine
• CAS No.: 107351-82-6
• Molecular Formula: C11H8 Br N
• Molecular Weight: 234.095
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20376532
• Nikkaji Number: J1.720.055K
• Wikidata: Q72511274
• Mol file: 107351-82-6.mol

Synonyms:2-bromo-5-phenylpyridine;107351-82-6;PYRIDINE, 2-BROMO-5-PHENYL-;MFCD04114195;SCHEMBL584462;DTXSID20376532;TVOAXRDXTGCPBB-UHFFFAOYSA-N;AKOS005064557;AB17966;DS-11122;SY032053;CS-0018829;FT-0649711;A21936;F30276;J-508418

Chemical Property of 2-Bromo-5-phenylpyridine

Chemical Property:

• Vapor Pressure: 0.000235mmHg at 25°C
• Melting Point: 75 °C
• Boiling Point: 335.3 ºCat 760 mmHg
• PKA: 0.41±0.10(Predicted)
• Flash Point: 156.6 ºC
• PSA: 12.89000
• Density: 1.426 g/cm³
• LogP: 3.51110
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 232.98401
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-5-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(C=C2)Br

Technology Process of 2-Bromo-5-phenylpyridine

There total 22 articles about 2-Bromo-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-5-iodo-pyridine (73290-22-9) + phenylboronic acid (98-80-6) → 2-bromo-5-phenyl-pyridine (107351-82-6)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 120 ℃; for 4h;

Reference yield: 88.0%

5-phenyl-pyridin-2-ylamine (33421-40-8) → 2-bromo-5-phenyl-pyridine (107351-82-6)

Guidance literature:

5-phenyl-pyridin-2-ylamine; With hydrogen bromide; sodium nitrite; In water; at -13 ℃;

With bromine; In water; at -9 - 20 ℃; for 20h;

Reference yield: 88.0%

2-bromo-5-iodo-pyridine (73290-22-9) + triphenylbismuthane (603-33-8) → 2-bromo-5-phenyl-pyridine (107351-82-6)

Guidance literature:

With potassium phosphate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 1h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2014.11.036

upstream raw materials:

2,5-dibromopyridine

bromobenzene

5-phenyl-pyridin-2-ylamine

6-bromopyridin-3-ylboronic acid

Downstream raw materials:

N-methyl-5-phenylpyridin-2-amine

2-methylamino-3-bromo-5-phenylpyridine

N²-methyl-5-phenylpyridine-2,3-diamine

2,4-bis(4-tert-butylphenyl)-6-[4-(5-phenylpyridin-2-yl)phenyl]-1,3,5-triazine