methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate

Base Information

Chemical Name:methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate
CAS No.:1403596-20-2
Molecular Formula:C₁₉H₂₈N₂O₃
Molecular Weight:332.443
Hs Code.:

Synonyms:methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate

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Chemical Property of methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate

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Technology Process of methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate

There total 8 articles about methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1403596-19-9
methyl 5-(azetidin-3-yl)-2-methyl-3-[methyl(oxan-4-yl)amino]benzoate

: 1403596-20-2
methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate

Guidance literature:: formaldehyd; methyl 5-(azetidin-3-yl)-2-methyl-3-[methyl(oxan-4-yl)amino]benzoate; With acetic acid; In 1,2-dichloro-ethane; for 0.0833333h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 20h;

With sodium hydrogencarbonate; In water; pH=7;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403596-20-2
methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 64 h

4.1: caesium carbonate / acetonitrile / 7 h / 80 °C

5.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / 90 h / 80 °C / Inert atmosphere

5.2: 1.5 h / 80 °C

6.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

6.2: pH 7 - 8

7.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

7.2: 20 h / 20 °C

7.3: pH 7

With chloro-trimethyl-silane; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; ethylene dibromide; trifluoroacetic acid; zinc; In ethanol; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1975-50-4
2-methyl-3-nitrobenzic acid

: 1403596-20-2
methyl 2-methyl-3-[methyl(oxan-4-yl)amino]-5-(1-methylazetidin-3-yl)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid / 5 h / 20 °C

1.2: Cooling

2.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

4.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

4.2: 64 h

5.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

5.2: 34 h / 20 °C

5.3: pH 7

6.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / 90 h / 80 °C / Inert atmosphere

6.2: 1.5 h / 80 °C

7.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

7.2: pH 7 - 8

8.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

8.2: 20 h / 20 °C

8.3: pH 7

With chloro-trimethyl-silane; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; iron; sodium carbonate; ammonium chloride; acetic acid; ethylene dibromide; trifluoroacetic acid; zinc; In ethanol; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;