1-(4-cyclohexylmercapto-phenyl)-ethanone

Base Information

• Chemical Name: 1-(4-cyclohexylmercapto-phenyl)-ethanone
• CAS No.: 100971-72-0
• Molecular Formula: C₁₄H₁₈OS
• Molecular Weight: 234.362
• Mol file: 100971-72-0.mol

Synonyms:1-(4-cyclohexylmercapto-phenyl)-ethanone

Chemical Property of 1-(4-cyclohexylmercapto-phenyl)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-cyclohexylmercapto-phenyl)-ethanone

There total 4 articles about 1-(4-cyclohexylmercapto-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Cyclohexanethiol (1569-69-3) + 4-Iodoacetophenone (13329-40-3) → 1-(4-cyclohexylmercapto-phenyl)-ethanone (100971-72-0)

Guidance literature:

With potassium phosphate; copper(l) iodide; L-proline; In N,N-dimethyl-formamide; at 80 ℃; for 40h;

DOI:10.1080/00397910600977533

Reference yield: 92.0%

Cyclohexanethiol (1569-69-3) + para-bromoacetophenone (99-90-1) → 1-(4-cyclohexylmercapto-phenyl)-ethanone (100971-72-0)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; (1,2-dimethoxyethane)dichloronickel(II); diisopropylammonium bis(catecholato)isobutylsilicate; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl-formamide; at 27 ℃; for 24h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00208

Reference yield: 81.0%

Cyclohexanethiol (1569-69-3) + 1-(4-fluorophenyl)ethanone (403-42-9) → 1-(4-cyclohexylmercapto-phenyl)-ethanone (100971-72-0)

Guidance literature:

With barium molybdate; potassium hydroxide; In acetonitrile; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c9nj05581a

upstream raw materials:

cyclohexyl phenyl sulphide

acetyl chloride

Cyclohexanethiol

4-Iodoacetophenone

Refernces

• 1、 Martín, M. Trinidad,Marín, Mario,Maya, Celia,Prieto, Auxiliadora,Nicasio, M. Carmen. "Ni(II) Precatalysts Enable Thioetherification of (Hetero)Aryl Halides and Tosylates and Tandem C?S/C?N Couplings". supporting information. p. 12320 - 12326. Retrieved 2021/08/09.
• 2、 Jouffroy, Matthieu,Kelly, Christopher B.,Molander, Gary A.. "Thioetherification via Photoredox/Nickel Dual Catalysis". supporting information. p. 876 - 879. Retrieved 2016/03/04.