BOC-4,4-DIFLUORO-L-PROLINAMIDE

Base Information

• Chemical Name: BOC-4,4-DIFLUORO-L-PROLINAMIDE
• CAS No.: 426844-50-0
• Molecular Formula: C₁₀H₁₆F₂N₂O₃
• Molecular Weight: 250.245
• Hs Code.: 2933990090
• Mol file: 426844-50-0.mol

Synonyms:(2S)-2-Aminocarbonyl-1-tert-butoxycarbonyl-4,4-difluoropyrrolidine;tert-Butyl (2S)-2-aminocarbonyl-4,4-difluoro-1-pyrrolidinecarboxylate

Chemical Property of BOC-4,4-DIFLUORO-L-PROLINAMIDE

Chemical Property:

• Vapor Pressure: 9.37E-06mmHg at 25°C
• Boiling Point: 372.8°C at 760 mmHg
• PKA: 15.50±0.40(Predicted)
• Flash Point: 179.3°C
• PSA: 72.63000
• Density: 1.26g/cm³
• LogP: 1.75460
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-4,4-Difluoro-L-prolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-4,4-DIFLUORO-L-PROLINAMIDE

There total 10 articles about BOC-4,4-DIFLUORO-L-PROLINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate (203866-17-5) → (S)-2-carbamoyl-4,4-difluoropyrrolidine-1-carboxylic acid tert-butyl ester (426844-50-0)

Guidance literature:

With ammonia; In methanol; at 0 - 20 ℃; for 12h;

Reference yield: 72.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline (203866-15-3) → (S)-2-carbamoyl-4,4-difluoropyrrolidine-1-carboxylic acid tert-butyl ester (426844-50-0)

Guidance literature:

1-hydroxy-pyrrolidine-2,5-dione; 1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline; With dicyclohexyl-carbodiimide; In dichloromethane; at 15 - 20 ℃; for 0.5h;

With ammonia; In methanol; dichloromethane; for 0.333333h;

Reference yield: 69.0%

1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline (203866-15-3) → (S)-2-carbamoyl-4,4-difluoropyrrolidine-1-carboxylic acid tert-butyl ester (426844-50-0)

Guidance literature:

1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline; With pivaloyl chloride; triethylamine; In dichloromethane; at -15 ℃; for 1h;

With ammonia; In dichloromethane; water; at -15 ℃; for 1h;

upstream raw materials:

1-(tert-butoxycarbonyl)-4,4-difluoro-L-proline

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

Downstream raw materials:

(2S)-4,4-difluoro-2-pyrrolidinecarboxamide hydrochloride

(S)-tert-butyl 2-(2-carbamoyl-4,4-difluoropyrrolidin-1-yl)-2-oxoethylcarbamate

tert-butyl (S)-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamate

(S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride