2--N''-<(S)-α-methylbenzyl>acetamide

Base Information

• Chemical Name: 2--N''-<(S)-α-methylbenzyl>acetamide
• CAS No.: 137348-63-1
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368

Synonyms:2--N''-<(S)-α-methylbenzyl>acetamide

Chemical Property of 2--N''-<(S)-α-methylbenzyl>acetamide

Chemical Property:

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Technology Process of 2--N''-<(S)-α-methylbenzyl>acetamide

There total 4 articles about 2--N''-<(S)-α-methylbenzyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-1-phenyl-ethylamine (2627-86-3) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → 2--N''-<(S)-α-methylbenzyl>acetamide (137348-63-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; at 0 ℃; for 5h;

DOI:10.1021/jo00125a029

Reference yield:

C11H15NOS + N-(Benzyloxycarbonyl)glycine (1138-80-3) → 2--N''-<(S)-α-methylbenzyl>acetamide (137348-63-1)

Guidance literature:

With dmap; In chloroform; at 70 ℃; for 10h; Inert atmosphere;

DOI:10.1021/ol403508

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → 2--N''-<(S)-α-methylbenzyl>acetamide (137348-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2 / CH₂Cl₂; dimethylformamide / 1.5 h / Ambient temperature

2: CH₂Cl₂ / 9 h / -15 °C

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(00)80465-6

upstream raw materials:

N-(benzyloxycarbonyl)glycyl chloride

(S)-1-phenyl-ethylamine

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

2-amino-N'-(α-phenylethyl)acetamide

(S,S)-1-benzoyl-2-tert-butyl-3-(α-phenylethyl)-1,3-imidazolidin-4-one

(R,S)-1-benzoyl-2-tert-butyl-3-(α-phenylethyl)-1,3-imidazolidin-4-one

2-N-(2,2'-dimethylpropyliden)amino-N'-(α-phenylethyl)acetamide

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