5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide

Base Information

Chemical Name:5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide
CAS No.:1427064-46-7
Molecular Formula:C₂₀H₂₂F₃N₃O₃
Molecular Weight:409.408
Hs Code.:

Synonyms:5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide

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Chemical Property of 5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide

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Technology Process of 5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide

There total 4 articles about 5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427064-92-3
5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

: 618-40-6
1-Methyl-1-phenylhydrazine

: 1427064-46-7
5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 25637-18-7
4-iodotetrahydropyran

: 1427064-46-7
5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc; chloro-trimethyl-silane / ethylene dibromide / 65 °C

1.2: Inert atmosphere

2.1: lithium hydroxide / water; tetrahydrofuran / 3 h / 40 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

With chloro-trimethyl-silane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; water; ethylene dibromide; N,N-dimethyl-formamide;

Reference yield:

: 1427064-91-2
5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

: 1427064-46-7
5-(tetrahydropyran-4-yl)-6-(2,2,2-trifluoroethoxy)nicotinic acid N′-methyl-N′-phenylhydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / 3 h / 40 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;