ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

Base Information

Chemical Name:ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate
CAS No.:1160175-54-1
Molecular Formula:C₂₁H₂₈F₃NO₇S
Molecular Weight:495.517
Hs Code.:

Synonyms:ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

Suppliers and Price of ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

There total 1 articles about ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1160175-53-0
ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenyl-4-(trifluoromethyl)hex-2-enoate

: 124-63-0
methanesulfonyl chloride

: 1160175-54-1
ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jo9005602

Reference yield: 33.0%

: 1160175-54-1
ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

: 2-methylpropyl zinc bromide

: 1160175-65-4
ethyl (2R,5S,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-isobutyl-6-phenyl-4-(trifluoromethyl)hex-3-enoate

: 1160175-64-3
ethyl (2S,5S,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-isobutyl-6-phenyl-4-(trifluoromethyl)hex-3-enoate

: ethyl (2R,5S,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-isobutyl-6-phenyl-4-(trifluoromethyl)hex-3-enoate

Guidance literature:: 2-methylpropyl zinc bromide; With copper(ll) bromide; In 1-methyl-pyrrolidin-2-one; hexane; toluene; at -30 ℃; for 0.5h;

ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate; In 1-methyl-pyrrolidin-2-one; hexane; toluene; at -30 - -10 ℃;

With ammonium hydroxide; ammonium chloride; In 1-methyl-pyrrolidin-2-one; hexane; toluene; at -10 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/jo9005602

Reference yield: 14.0%

: 1160175-54-1
ethyl (4S,5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4-(methylsulfonyloxy)-6-phenyl-4-(trifluoromethyl)hex-2-enoate

: 676-58-4
methylmagnesium chloride

: 1160175-63-2
ethyl (2R,5S,3E)-5-[N-(tert-butoxycarbonyl)amino]-2-methyl-6-phenyl-4-(trifluoromethyl)hex-3-enoate

: 1160175-62-1
ethyl (2S,5S,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-methyl-6-phenyl-4-(trifluoromethyl)hex-3-enoate

: ethyl (2R,5S,3Z)-5-[N-(tert-butoxycarbonyl)amino]-2-methyl-6-phenyl-4-(trifluoromethyl)hex-3-enoate

: C₂₁H₂₈F₃NO₄

Guidance literature:: With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; at -78 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/jo9005602