4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

Base Information

Chemical Name:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid
CAS No.:220996-88-3
Molecular Formula:C₁₉H₂₄F₃NO₆
Molecular Weight:419.398
Hs Code.:

Synonyms:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

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Chemical Property of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

Chemical Property:

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Technology Process of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

There total 9 articles about 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 220996-87-2
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetonitrile

: 220996-88-3
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

Guidance literature:: With hydrogenchloride; acetic acid;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 4-(4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 220996-87-2
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetonitrile

: 220996-88-3
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In concentrated aqueous HCl; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 220996-81-6
(4-bromo-2-(trifluoromethoxy)phenyl)methanol

: 220996-88-3
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-2-(trifluoromethoxy)phenylacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

2: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

3: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

4: 95 percent / Bu₄NF / tetrahydrofuran

5: 85 percent / CBr₄, Ph₃P / diethyl ether

6: 90 percent / dimethylformamide

7: 75 percent / conc. HCl, HOAc

With hydrogenchloride; dmap; n-butyllithium; Trimethyl borate; carbon tetrabromide; tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00181-X